Objectives: To estimate long-term clinical outcomes of using rilpivirine/tenofovir/emtricitabine (single tablet regimen) in treatment of naïve patients with HIV-1 RNA< 100 000 copies/ml in the Russian Federation. MethOds: The mathematical model was developed in Microsoft Office 2013. The time horizon was 5 years. The model included two submodels: Markov's model and tree-decision model. The following outcome measures were used in present study: Number of deaths, Years of life lost, Number of hospitalizations. All calculations were based on results of published clinical, epidemiological and social researches. Data for patients with HIV was obtained from prior epidemiological studies that had been provided in the Russian Federation. Results: The number of deaths on rilpivirine/tenofovir/emtricitabine scheme (single tablet regimen) was 12% and 15% less, the number of YLL was 9% and 12% less and Number of hospitalizations was 19,91% and 19,88% less than on the schemes efavirenz + tenofovir/ emtricitabin (multi-pill regimen) and lopinavir + tenofovir/ emtricitabin (multi-pill regimen), respectively. cOnclusiOns: Results obtained with present model showed that treatment naïve patients with HIV-1 RNA< 100 000 copies/ml using rilpivirine/tenofovir/emtricitabine scheme (single tablet regimen) can be associated with better long-term outcomes compared to alternative multi-pill schemes.
A871females in Mexico. The model compared baseline coverage of 70% for two doses of the quadrivalent vaccine versus bivalent vaccine. Mexico specific data was used from literature where available; default values were used otherwise. Input data included demographic, behavioral, epidemiological and screening parameters, and direct treatment costs of HPV-related morbidities from a public health perspective. Results: In a 100-year period, as compared to a two dose 70% bivalent vaccination program, a 70% quadrivalent vaccination program coverage would result in reductions of HPV 6/11-related disease incidence at the population level as follows: genital warts in females (83%), genital warts in males (81.4%) and HPV6/11-related CIN1 (82%) . This would translate into a reduction of HPV 6/11-related disease cost of 59.1%, 56.3%, and 55.7% for genital warts among females, genital warts among males, and HPV6/11-related CIN1, respectively. Under the model assumptions, over a 100 year period, the total HPV6/11/16/18-related disease costs avoided would be over $1.7 billion Mexican Pesos. Thesincremental cumulative QALYs gained per 100,000 by HPV 6/11/16/18-related disease over 100 years would be 30.31 when compared with an HPV16/18 vaccination program. ConClusions: In Mexico, routine vaccination of 9-11 year old females with a quadrivalent HPV6/11/16/18 vaccine has incremental economic, public health, and humanistic impact as compared to a bivalent HPV 16/18 vaccine
studies. Outcome measures were life years, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICER). Future costs and outcomes being discounted at 3% per annum. Probabilistic sensitivity analysis (PSA) was conducted to deal with uncertainties around parameters. Results: The third regimen, 3) DRV/ r+RAL+TDF+3TC, was the lowest lifetime cost, which was 5.7 million baht, and approximately increased 10 QALYs. The incremental cost-effectiveness ratio for the third regimen compared with current practice was ฿ 332,227. ConClusions: All alternative regimens for treatment experienced patients with HIV drug resistance in Thailand were not currently cost-effective at the willingness to pay (WTP) 160,000 baht/QALYs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.