BackgroundThe skin of atopic dermatitis (AD) patients has a high susceptibility to Staphylococcus aureus colonization, and the toxins produced by S. aureus may aggravate AD by acting as superantigens.ObjectiveThe purpose of this study was to evaluate the relationship of the skin barrier function, colonization of S. aureus, and the clinical severity of AD. We also examined the predominant toxin genes produced in Korean AD patients.MethodsThirty-nine patients with AD were evaluated for clinical severity and skin barrier function by using Severity Scoring of Atopic Dermatitis (SCORAD) index and transepidermal water loss (TEWL). S. aureus was isolated from the forearm, popliteal fossa, and anterior nares of AD patients (n=39) and age-matched controls (n=40); the toxin genes were analyzed by performing multiplex polymerase chain reaction.ResultsTEWL showed a statistically significant correlation with clinical severity in patients with AD (p<0.05). TEWL was correlated with the number of S. aureus colonization sites and the presence of nasal colonization, but these results were not statistically significant. S. aureus strains were isolated in 64.1% of the 39 AD patients. The SCORAD index and AD severity were strongly correlated with the number of colonization sites. The predominant toxin gene found in AD patients was staphylococcal enterotoxin a (sea) only, which was produced in 52.6% of patients. The toxin genes sea and toxic shock syndrome toxin-1 (tsst-1) were found together in 42.1%, while tsst-1 only was found in 5.3% of the patients.ConclusionS. aureus strains were isolated in 64.1% of the 39 AD patients. Skin barrier function, as measured by TEWL, revealed a statistically significant correlation with clinical severity in AD patients. The SCORAD index and severity of AD was strongly correlated with the number of colonization. The most common toxin gene was sea in the Korean AD patients and this gene might have an important role in the pathogenesis of AD.
Abstract:Boilers of large-sized coal-fired power plants are being operated under very poor conditions such as continuous operation or repeating of start-up and shutdown for a stable supply of electricity. Thus periodic inspection and maintenance are required to ensure reliability of operation. The loads of existing scaffolding systems for the maintenance of boilers are concentrated in the lower parts structurally, which may cause a serial collapse of the overall scaffolding system when there are problems in some members. Therefore, in this study, a safe furnace scaffolding system is developed by dispersing the loads in the upper part, as well as minimizing the hazards of serial collapsing. In addition, for cases where the direct installation of furnace scaffolding is challenging owing to the structure of the boiler tube, a lifting system for the installation of furnace scaffolding is developed so that furnace scaffolding can be supported to secure the integrity of the power generating facility. § 이 논문은 대한기계학회 창립 70주년 기념 학술대회
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