Nowadays, aerial covered conductors (CC) are increasingly used in many places of the world due to their higher operational reliability, reduced construction space and effective protection for wildlife animals. In spite of these advantages, a major challenge of using CC is that the ordinary upstream protection devices are not able to detect the phase-to-ground faults and the frequent tree/tree branch hitting conductor events on such conductors. This is because these events only lead to partial discharge (PD) activities rather than overcurrent signatures typically seen on bare conductors. To solve this problem, in recent years, ENET Centre in Czech Republic (ENET) devised a simple meter to measure the voltage signal of the electric stray field along CC, aiming to detect the above hazardous PD activities. In 2018, ENET shared a large amount of waveform data recorded by their meter on Kaggle, the world's largest data science collaboration platform, encouraging worldwide experts to develop an effective pattern recognition method for the acquired signals.For this challenge, we developed a unique method based on time-series decomposition and Long Short-Term Memory Network (LSTM) in addition to unique feature engineering process to recognize PD activities on aerial covered conductors. The proposed method is tested on the ENET public dataset and compared to various traditional classification methods. It demonstrated superior performance and great practicality.

The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis-acting genetic elements that control the expression of the CYP3As remain uncharacterized. Using chromatin conformation capture (4C assays), we detected reciprocal interaction between a distal regulatory region (DRR) and the CYP3A4 promoter. The DRR colocalizes with a variety of enhancer marks and was found to promote transcription in reporter assays. CRISPR-mediated deletion of the DRR decreased expression of CYP3A4, CYP3A5, and CYP3A7, supporting its role as a shared enhancer regulating the expression of three CYP3A genes. Using reporter gene assays, we identified two single-nucleotide polymorphisms (rs115025140 and rs776744/rs776742) that increased DRR-driven luciferase reporter expression. In a liver cohort (n = 246), rs115025140 was associated with increased expression of CYP3A4 mRNA (1.8-fold) and protein (1.6-fold) and rs776744/rs776742 was associated with 1.39-fold increased expression of CYP3A5 mRNA. The rs115025140 is unique to the African population and in a clinical cohort of African Americans taking statins for lipid control rs115025140 carriers showed a trend toward reduced statin-mediated lipid reduction. In addition, using a published cohort of Chinese patients who underwent renal transplantation taking tacrolimus, rs776744/rs776742 carriers were associated with reduced tacrolimus concentration after adjusting for CYP3A5*3. Our results elucidate a complex regulatory network controlling expression of three CYP3A genes and identify two novel regulatory variants with potential clinical relevance for predicting CYP3A4 and CYP3A5 expression. Study Highlights WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?There is limited knowledge concerning distal cis-acting regulatory elements and genetic variants controlling expression of the CYP3As.

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