THE production of fatty livers in rats by the administration of a diet consisting of mixed grain and 40 p.c. of beef fat has been demonstrated by Best, Hershey and Huntsman [1932]. The work of other authors has shown that fatty livers may be produced by feeding animals on diets containing cholesterol. Thus the results of Chalatow [1912], Chalatow and Anitschow [1913], Bailey [1916], McMeans [1915], Yuasa [1928], Kimura [1931] all show directly or indirectly that diets containing cholesterol cause a change in the nature or an increase in the amounts of the liver lipoids. More recently Okey [1933 a] showed that the dietary administration of 1 p.c. of cholesterol to rats caused a large increase in the lipoid content of the liver, and in particular a remarkable rise in the amount of total cholesterol, far the greater part of which was present as cholesteryl esters. Similar results have been reported by Chanutin and Ludewig [1933]. Thus fatty livers may be produced either by feeding to animals certain diets of high fat content or by inclu-
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