To introduce phase-based conductivity mapping from a configuration space analysis. Methods: The frequency response function of balanced SSFP (bSSFP) is used to perform a configuration space analysis. It is shown that the transceive phase for conductivity mapping can be directly obtained by a simple fast Fourier transform of a series of phase-cycled bSSFP scans. For validation, transceive phase and offresonance mapping with fast Fourier transform is compared with phase estimation using a recently proposed method, termed PLANET. Experiments were performed in phantoms and for in vivo brain imaging at 3 T using a quadrature head coil. Results: For fast Fourier transform, aliasing can lead to systematic phase errors. This bias, however, decreases rapidly with increasing sampling points. Interestingly, Monte Carlo simulations revealed a lower uncertainty for the transceive phase and the off-resonance using fast Fourier transform as compared with PLANET. Both methods, however, essentially retrieve the same phase information from a set of phase-cycled bSSFP scans. As a result, configuration-based conductivity mapping was successfully performed using eight phase-cycled bSSFP scans in the phantoms and for brain tissues. Overall, the retrieved values were in good agreement with expectations. Conductivity estimation and mapping of the field inhomogeneities can therefore be performed in conjunction with the estimation of other quantitative parameters, such as relaxation, using configuration theory. Conclusions: Phase-based conductivity mapping can be estimated directly from a simple Fourier analysis, such as in conjunction with relaxometry, using a series of phase-cycled bSSFP scans.
Purpose To show that for tissues the conspicuous asymmetries in the frequency response function of bSSFP can be mitigated by using a short enough TR. Theory and Methods Configuration theory indicates that bSSFP becomes apparently “pure” (i.e., exhibiting a symmetric profile) in the limit of TR →0. To this end, the frequency profile of bSSFP was measured as a function of the TR using a manganese‐doped aqueous probe, as well as brain tissue that was shown to exhibit a pronounced asymmetry due to its microstructure. The frequency response function was sampled using N=72 (phantom) and N=36 (in vivo) equally distributed linear RF phase increments in the interval [0,2π). Imaging was performed with 2.0 mm isotropic resolution over a TR range of 1.5–8 ms at 3 and 1.5 T. Results As expected, pure substances showed a symmetric TR‐independent frequency profile, whereas brain tissue revealed a pronounced asymmetry. The observed asymmetry for the tissue, however, decreases with decreasing TR and gives strong evidence that the frequency response function of bSSFP becomes symmetric in the limit of TR →0, in agreement with theory. The limit of apparently pure bSSFP imaging can thus be achieved for a TR ∼ 1.5 ms at 1.5 T, whereas at 3 T, tissues still show some residual asymmetry. Conclusion In the limit of short enough TR, tissues become apparently pure for bSSFP. This limit can be reached for brain tissue at 1.5 T with TR ∼ 1–2 ms at clinically relevant resolutions.
Brain relaxometry with phase-cycled bSSFP shows systematically lower T1 values, if compared to spoiled-GRE or inversion-recovery spin echo methods. One explanation can be the pronounced asymmetry in the bSSFP's frequency profile, observed for tissues. It was recently shown that this asymmetry decreases towards shorter TR, possibly leading to an adjustment of T1 estimates from bSSFP to spoiled-GRE. Here, it was investigated how T1 and T2 quantification is influenced by TR. Contrary to expectation, a stronger mismatch between bSSFP and spoiled-GRE was observed towards shorter TR. The origin of this mismatch can thus not be attributed to the bSSFP profile asymmetry.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.