Objective: Analyze the quality of life of HIV seropositive women. Methods: Cross-sectional study including 40 women selected through non-probabilistic sampling. The questionnaire WHOQOL-HIV bref was the research instrument employed, considering the six domains of the instrument and socio-demographic and clinical aspects. Data analysis was performed using the KolmogorovSmirnov test to analyze the normality of sampling average distributions, and the Mann-Whitney and KruskalWallis tests to analyze the difference between averages or medians of the scores for quality of life. The Spearman coefficient was used for potential correlations. Results: According to the questionnaire, the Spirituality domain (average=59.5) reported the highest score, while the Environment domain (average=52.1) scored lowest. The average age was 41 years old; 97.5% declared themselves to be heterosexual; and 80.0% used antiretroviral treatment. Conclusion: Spirituality was the best-performing domain, followed by the Physical domain. The lowest average scores were observed for the Environment and Social Relations domains. ResumoObjetivo: Analisar a qualidade de vida de mulheres portadoras do HIV. Métodos: Estudo transversal que incluiu 40 mulheres selecionadas por amostra não-probabilística. O instrumento de pesquisa foi o questionário WHOQOL-HIV bref, considerando-se os seis domínios do instrumento e os aspectos sociodemográficos e clínicos. Para análise dos dados foi realizado o teste de Kolmogorov-Smirnov para a normalidade das distribuições de médias amostrais e os testes Mann-Whitney e Kruskal-Wallis para analisar a diferença entre as médias ou medianas dos escores de qualidade de vida. O coeficiente de Spearman foi utilizado para possíveis correlações. Resultados: Segundo o questionário, o domínio Espiritualidade (média = 59,5) apresentou maior escore e o domínio Meio Ambiente (média = 52,1) o menor escore obtido. A média da idade foi de 41 anos, 97,5% declararam ser heterossexuais, 80,0% utilizavam tratamento antirretroviral. Conclusão: A espiritualidade foi o domínio com melhor desempenho, seguido do domínio Físico. Os menores escores médios foram observados nos domínios Meio Ambiente e Relações Sociais.
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