l-Methionine γ-lyase (MGL) is a PLP-dependent enzyme which catalyzes the α, γ-elimination reaction in sulfur containing amino acids, such as L-methionine and L-cysteine. Its major applications are on metabolic restriction of methionine to cancer cells, food industry (cheese flavor) and for the synthesis of d and l-homoalanine. Herein, we present the immobilization and use of this new immobilized biocatalyst under batch and continuous-flow conditions. The best optimized continuousflow condition allowed 89 % conversion in 30 min of residence time with good recyclability of the biocatalyst.
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