Background: Base J regulates Pol II transcription in trypanosomatids and is synthesized in two steps involving DNA hydroxylation and glucosylation. Results: JGT catalyzes the transfer of glucose from uridine diphosphoglucose to hmU in DNA. Conclusion: JGT is the glucosyltransferase involved in base J synthesis. Significance: JGT is the first known glucosyltransferase that modifies eukaryotic DNA.
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