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Atmospheric reanalyses covering the European region are mainly available as part of relatively coarse global reanalyses. The aim of this article is to present the development and evaluation of a next generation regional reanalysis for the European CORDEX EUR-11 domain with a horizontal grid spacing of approximately 6 km. In this context, a reanalysis is understood to be an assimilation of heterogeneous observations with a physical model such as a numerical weather prediction (NWP) model. The reanalysis system presented here is based on the NWP model COSMO by the German Meteorological Service (Deutscher Wetterdienst) using a continuous nudging scheme. In order to assess the added value of data assimilation, a dynamical downscaling experiment has been conducted, i.e. an identical model set-up but without data assimilation. Both systems have been evaluated for a 1 year test period, employing standard measures such as analysis increments, biases, or log-odds ratios, as well as tests for distributional characteristics. An important aspect is the evaluation from different perspectives and with independent measurements such as satellite infrared brightness temperatures using forward operators, integrated water vapour from GPS stations, and ceilometer cloud cover. It can be shown that the reanalysis better resolves local extreme events; this is basically an effect of the higher spatio-temporal resolution, as known from dynamical downscaling approaches. However, an important criterion for regional reanalyses is the coherence with independent observations of high temporal and spatial resolution, resulting in significant improvement over dynamical downscaling. The system is intended to become operational within a year, continuously reprocessing and evaluating longer time periods. The reanalysis data are planned to become available to the research community within a year.

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Research on astronaut health and model organisms have revealed six features of spaceflight biology that guide our current understanding of fundamental molecular changes that occur during space travel. The features include oxidative stress, DNA damage, mitochondrial dysregulation, epigenetic changes (including gene regulation), telomere length alterations, and microbiome shifts. Here we review the known hazards of human spaceflight, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration. We also discuss the essential issues related to the health and safety of astronauts involved in future missions, especially planned long-duration and Martian missions.

The impact of 3D groundwater dynamics as part of the hydrologic cycle is rarely considered in regional climate simulation experiments. However, there exists a spatial and temporal connection between groundwater and soil moisture near the land surface, which can influence the land surface‐atmosphere feedbacks during heat waves. This study assesses the sensitivity of bedrock‐to‐atmosphere simulations to groundwater representations at the continental scale during the European heat wave 2003 using an integrated fully coupled soil‐vegetation‐atmosphere model. The analysis is based on the comparison of two groundwater configurations: (1) 3D physics‐based variably saturated groundwater dynamics and (2) a 1D free drainage (FD) approach. Furthermore, two different subsurface hydrofacies distributions (HFD) account for the uncertainty of the subsurface hydraulic characteristics, and ensemble simulations address the uncertainty arising from different surface‐subsurface initial conditions. The results show that the groundwater representation significantly impacts land surface‐atmosphere processes. Differences between the two groundwater configurations follow subsurface patterns, and the largest differences are observed for shallow water table depths. While the physics‐based setup is less sensitive to the HFD, the parameterized FD simulations are highly sensitive to the hydraulic characteristics of the subsurface. An analysis of variance shows that both, the groundwater configuration and the HFD, induce variability across all compartments with decreasing impact from the subsurface to the atmosphere, while the initial condition has only a minor impact.