A tutorial review showcasing how peptide–drug conjugates can offer the versatility needed for a successful drug discovery approach, their problems and future opportunities.
We describe the development of a CAM4712, a novel CK2α inhibitor which does not interact with the ATP binding site and shows improved properties over the first-generation inhibitor CAM4066.
This work describes the efficient development of functionalised, cell-permeable, and stable peptide inhibitors of the protein–protein interaction of CK2.
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