Cirrhosis describes the development of excess fibrous tissue around regenerative nodules in response to chronic liver injury and usually leads to irreversible organ damage and end-stage liver disease. During the development of cirrhosis, the formation of collagenous scar tissue is paralleled by a reorganization and remodeling of the hepatic vascular system. To date, macrovascular remodeling in various cirrhosis models has been examined using three-dimensional (3D) imaging modalities, while microvascular changes have been studied mainly by two-dimensional (2D) light microscopic and electron microscopic imaging. Here, we report on the application of high-resolution 3D synchrotron radiation-based microtomography (SRμCT) for the study of the sinusoidal and capillary blood vessel system in three murine models of advanced parenchymal and biliary hepatic fibrosis. SRμCT facilitates the characterization of microvascular architecture and identifies features of intussusceptive angiogenesis in progressive liver fibrosis in a non-destructive 3D manner.
This article takes on the experience and narrative of two Brazilian reporters, Helena Salem and Adriana Mabilia, in the coverage of the Palestine question. In different moments, both summarize as books an intense trajectory of reporting on the subject. Palestinians, the new Jews (Palestinos, os novos judeus in the original), published in 1977 by Salem, and Trip to Palestine: outdoor prison (Viagem à Palestina: prisão a céu aberto), published in 2013 by Mabilia, project over time some possible meanings for the conflict between Israeli and Palestinians. The cartography they compose results from the narrative position and the politics of the sources explored by them. Given that both women come from a developing country and are journalists, they are personally interested in problematizing the conditions that made possible the time and space chosen for their exploration. The clues they offer in their narration do not reprise naturalizations on the subject, an effort which allows also for a debate on some aspects of the practice of journalism based on their books.
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