We designed a phase II study evaluating the upfront combination of clofarabine and daunorubicin in acute myeloid leukemia (AML) patients ≥60 years old. The median age of the 21 patients was 69 (range 60–85) years. Fourteen patients (67%) had unfavorable risk features. The principal toxicities were grade ≥3 infections and prolonged myelosuppression. Three (14%) deaths occurred from infectious complications. Six (28.6%) patients achieved complete remission including three (21.4%) of 14 patients with unfavorable AML. The median disease-free survival was 6.8 months and the median overall survival was 11.2 months.
The production, shipping, usage, and disposal of consumer goods have a substantial impact on greenhouse gas emissions and the depletion of resources. Modern retail platforms rely heavily on Machine Learning (ML) for their search and recommender systems. Thus, ML can potentially support efforts towards more sustainable consumption patterns, for example, by accounting for sustainability aspects in product search or recommendations. However, leveraging ML potential for reaching sustainability goals requires data on sustainability. Unfortunately, no open and publicly available database integrates sustainability information on a product-by-product basis. In this work, we present the GreenDB, which fills this gap. Based on search logs of millions of users, we prioritize which products users care about most. The GreenDB schema extends the well-known schema.org Product definition and can be readily integrated into existing product catalogs to improve sustainability information available for search and recommendation experiences. We present our proof of concept implementation of a scraping system that creates the GreenDB dataset.
Patients with myelodysplastic syndrome who fail hypomethylating agents have a very short median survival and about 25% risk of disease transformation to acute myeloid leukemia. We report our experience with low-dose protracted oral clofarabine in one patient who achieved stable disease for more than two years after failing 5-azacitidine.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.