Recent studies indicate that vascular stiffening and associated remodeling of the proximal pulmonary arteries, due to pulmonary hypertension, may play a critical role in the progression of the disease and ultimate cardiac failure [1]. While progress has been made in the understanding of active and passive arterial mechanics of whole arteries, comparatively little experimental work has been done on the role of the major extracellular structural proteins, collagen and elastin, in determining baseline arterial mechanics and modulating behavior during vascular remodeling [2, 3]. Here, we examine the methods to determine the specific role of elastin in arterial mechanics as it relates to pulmonary hypertension.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.