Cl renal,iv ; renal clearance; Cl h,iv,blood , hepatic blood clearance; C max , maximum observed plasma concentration; CVb, between participant variability; CYP, cytochrome P450; DDI, drug-drug interaction; DMSO, dimethyl sulfoxide; EDTA, ethylenediaminetetraacetic acid; E h , hepatic extraction ratio; F, absolute oral bioavailability; fa, fraction of linerixibat absorbed; fg, fraction escaping first-pass gut metabolism; F h , first pass liver extraction; GI, gastrointestinal; IBAT, ileal bile acid transporter; IC 50 , half maximal inhibitory concentration; ICRP, International Commission on Radiological Protection; IV, intravenous; IVIVE, in vitro-to-in vivo extrapolation; LC-MS/MS, liquid chromatography with tandem mass spectrometry; LLQ, lower limit of quantification; LSC, liquid scintillation counting; PBC, primary biliary cholangitis; PK, pharmacokinetics; QC, quality control; Qh, hepatic blood flow; SD, standard deviation; t 1/2 , half-life; V ss , volume of distribution; V z , terminal volume