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The term “Frequently asked questions” (FAQ) refers to a query that is asked repeatedly and produces a manually constructed response. It is one of the most important factors influencing customer repurchase and brand loyalty; thus, most industry domains invest heavily in it. This has led to deep-learning-based retrieval models being studied. However, training a model and creating a database specializing in each industry domain comes at a high cost, especially when using a chatbot-based conversation system, as a large amount of resources must be continuously input for the FAQ system’s maintenance. It is also difficult for small- and medium-sized companies and national institutions to build individualized training data and databases and obtain satisfactory results. As a result, based on the deep learning information retrieval module, we propose a method of returning responses to customer inquiries using only data that can be easily obtained from companies. We hybridize dense embedding and sparse embedding in this work to make it more robust in professional terms, and we propose new functions to adjust the weight ratio and scale the results returned by the two modules.

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Extensive progress in understanding the molecular mechanisms of cancer growth and proliferation has led to the remarkable development of drugs that target cancer-driving molecules. Most target molecules are proteins such as kinases and kinase-associated receptors, which have enzymatic activities needed for the signaling cascades of cells. The small molecule inhibitors for these target molecules greatly improved therapeutic efficacy and lowered the systemic toxicity in cancer therapies. However, long-term and high-dosage treatment of small inhibitors for cancer has produced other obstacles, such as resistance to inhibitors. Among recent approaches to overcoming drug resistance to cancers, targeted protein degradation (TPD) such as proteolysis-targeting chimera (PROTAC) technology adopts a distinct mechanism of action by which a target protein is destroyed through the cellular proteolytic system, such as the ubiquitin–proteasome system or autophagy. Here, we review the currently developed PROTACs as the representative TPD molecules for cancer therapy and the N-degrons of the N-degron pathways as the potential TPD ligands.

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