This study aimed to identify the effects of health-related quality of life on depression in middle-aged moderate drinking women and hazardous drinking women. This paper presents a secondary data analysis of raw data from the 2020 Korea National Health and Nutrition Examination Survey conducted by the Korea Disease Control and Prevention Agency. This study was conducted on women aged 40~64 years who had been drinking alcohol over the past 12 months. A total of 909 participants were selected for analysis. The research tools were drinking, health-related quality of life, and depression. Data analysis was performed by SPSS/WIN v25.0 using descriptive statistics, t-test, oneway ANOVA, and multiple regression analysis. As a factor influencing depression, in moderate drinking woman, the factors affecting depression were stress, health-related quality of life, subjective health, sleep time, and economic activity in the order of importance. In hazardous drinking woman, the factors affecting depression were health-related quality of life, stress, subjective health, drinking, smoking, and education in the order of importance. In order to prevent depression in middle-aged women, it is necessary to practice moderate drinking and manage risk factors for depression. Through this, the quality of life of middle-aged women will be improved, helping to prevent depression, and will have a positive impact on the life of the elderly.
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