A significant amount of the literature is focused on converters that supply the required voltage with low input-current ripple to electronic devices. A hybrid converter that combines boost and Cuk converters was developed recently. This hybrid converter achieved a relatively low input-current ripple based on earlier strategies. This paper proposes a new model that simulates a hybrid power converter system using a unified evolutionary algorithm (EA). As part of this paper, we present an improved framework for a hybrid power converter. Moreover, a unified EA is developed to incorporate differential evolution (DE) and genetic algorithm (GA) properties in order to analyze the proposed modified hybrid power converter. This research describes a modified hybrid power converter that optimizes the zero-ripple duty cycle (Dz) through the proposed algorithm for minimizing the input-current ripple. Based on our simulation results, comparing the proposed method with the baseline algorithm reveals that the proposed approach is significantly more efficient than the baseline algorithm and achieves the minimum input-current ripple in different gain values. In addition, we observe that the proposed algorithm performs better than the DE and GA algorithms in terms of obtaining low input-current ripple results. Therefore, the proposed hybrid algorithm is becoming more efficient with hybridization.
Sphingolipids such as ceramide and glycosylceramide have recently attracted intense research interests because of their roles as signalling molecules in many important physiological processes, such as apoptosis, inflammation and immune responses. Their well-defined modular structures are ideally amenable to library formation for medicinal chemistry investigations. We have developed practical, divergent synthetic routes to sphingosine and phytosphingosine isomers as well as to carba-sugar analogues of all D-aldohexopyranose isomers toward these goals. And then we have proceeded to prepare ceramide libraries, composed of more than 500 compounds each, based on these sphingosine and phytosphingosine isomers, and demonstrated their utility in cell-based bioassays involving activation of NF-KB and induction of apoptosis. We are also in the process of forming libraries of mono-glycosylceramide and mono-carba-glycosylceramide.
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