In this study, a fully integrated electroencephalogram/functional near-infrared spectroscopy (EEG/fNIRS) brain monitoring system was designed to fulfill the demand for a miniaturized, light-weight, low-power-consumption, and low-cost brain monitoring system as a potential tool with which to screen for brain diseases. The system is based on the ADS1298IPAG Analog Front-End (AFE) and can simultaneously acquire two-channel EEG signals with a sampling rate of 250 SPS and six-channel fNIRS signals with a sampling rate of 8 SPS. AFE is controlled by Teensy 3.2 and powered by a lithium polymer battery connected to two protection circuits and regulators. The acquired EEG and fNIRS signals are monitored and stored using a Graphical User Interface (GUI). The system was evaluated by implementing several tests to verify its ability to simultaneously acquire EEG and fNIRS signals. The implemented system can acquire EEG and fNIRS signals with a CMRR of −115 dB, power consumption of 0.75 mW/ch, system weight of 70.5 g, probe weight of 3.1 g, and a total cost of USD 130. The results proved that this system can be qualified as a low-cost, light-weight, low-power-consumption, and fully integrated EEG/fNIRS brain monitoring system.
This paper describes an intrafascicular neural interface for peripheral nerve implantation. The flexible penetrating microelectrode array with varying lengths (vl-FPMA), interconnection cable, wireless recording and stimulator modules were designed and fabricated to detect neural signals from the peripheral nerves or to stimulate them. The vl-FPMA consisted of silicon needles and polydimethylsiloxane (PDMS) platform supporting the needles. The length of electrode needles varied from 600 to 1000 μm. The interconnection cable was fabricated as parylene-metal-parylene sandwiched structure. The wireless recording/stimulation modules were also developed and connected with the electrodes. The integrated system was implanted in the sciatic nerve of beagles and the recording capability of the integrated system was demonstrated successfully.
A low-noise, wide-bandwidth DNA readout instrument for nanopore applications is presented. Owing to hardware simplicity and reliability, a resistive-feedback transimpedance amplifier (rf-TIA) is adopted as the headstage for the readout instrument. However, to achieve a high gain and low input noise, its high feedback resistance induces a high parasitic capacitance, thus significantly limiting the 3 dB bandwidth. To drastically reduce the parasitic capacitance and widen the bandwidth, a novel rf-TIA architecture is fabricated that utilises a splitresistor technique for the high feedback resistor. This is demonstrated in a benchtop test employing an α-haemolysin nanopore.
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