Cardiac myxomas originating from the left ventricular free wall are extremely rare. A 32-year-old Swiss male was found to have a 5 x 3 x 3 cm myxoma originating from the left ventricular free wall using transthoracic echocardiography. The tumour was successfully treated by surgical excision but the mitral valve could not be preserved because of an untypical interference of the myxoma with the subvalvular apparatus.
Langendorff-perfused rabbit heart is a suitable model for studying short-term electrophysiologic changes due to both rapid pacing and atrial dilation. AERPs are shortened to a similar extent by both mechanisms, whereas a combination of the two leads to more pronounced AERP reduction. Calcium overload plays a crucial role in short-term electrophysiologic changes caused by atrial dilation, whereas atrial ischemia or acidosis has no significant impact.
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