Psychological stress has been linked empirically with dysregulation of facets of the human immune system, yet these effects are not the same in every situation or population. Recent research has made strides towards understanding risk factors for immune dysregulation as well as why these risks occur. This review discusses mechanisms and mediators underlying the stress-immune relation, the role of context in determining whether an immunologic responses to stress is adaptive versus maladaptive, and the stress-immune relation in populations including children exposed to early adversity, older adults, and individuals with clinical diagnoses. The reviewed work holds great promise for further elucidating the circumstances under which psychological stress has immunological consequences, and provides new directions for work in this field.

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Compromised respiratory sinus arrhythmia (RSA, i.e., low cardiac vagal control) frequently characterizes clinically depressed adults and also has been detected in infants of depressed mothers; however, its existence has not been established in older at-risk offspring. We investigated developmental patterns of RSA in a sample of 163 5-14 year-old children, who were either at high risk for depression (due to having a parent with a childhood-onset mood disorder) or low-risk for depression. We hypothesized that high-risk children have lower resting RSA than do low-risk children, which could reflect atypical developmental trajectories. Children's RSA was assessed during resting baseline periods on multiple occasions, typically one-year apart. Linear growth modeling indicated a group by age interaction. Low-risk children (but not the high-risk children) exhibited a significantly increasing trajectory in resting RSA with age. Mood disorders in offspring did not account for the Group X Age interaction effect. Our study provides new evidence that children at high risk for depression have an atypical developmental trajectory of RSA across late childhood.

Although communication technology is beneficial to maintain important close relationships, not all findings suggest that communication technology use between college students and their parents is indicative of positive adjustment or relational qualities. A study in 2009 found that only 24.2% of college students used a social networking site (SNS) to communicate with a parent, yet those students reported more loneliness, anxious attachment, and conflict with their parent (Gentzler et al., 2011 ). Because technology and trends in use change rapidly, we investigated a new cohort of college students 2 years later to determine if rates of using communication technology with parents and their links to student adjustment have changed. Comparisons between 2009 and 2011 samples indicated that in-person contact and telephone use did not vary across cohorts. However, texting and SNS use with parents became more common, and using e-mail with parents declined. Consistent with the 2009 data, students' phone use with parents was related to positive relationship qualities (satisfaction, intimacy, support, instrumental aid). In the new 2011 sample, e-mail was linked to aid. However, the present findings indicate students' SNS use with parents is no longer linked to maladaptive outcomes. The study highlights how quickly the use and implications of communication technology changes, and suggests that communication patterns may reflect broader psychosocial adjustment and parent-child dynamics.

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