We have prepared four N-substituted hydroxypyridinones
containing alcohol and morpholine groups. Complexes of the type
cis-MoO2L2,
where L represents the hydroxypyridinonato ligands have also been synthesized.
The ethanolamine derivative,
cis-MoO2(hep)2
(5), has been characterized by an X-ray diffraction study whereby the
pyridinone ligands are bound to molybdenum in a cis
bidentate fashion via the deprotonated hydroxy groups and the ketone moieties.
Crystals of (5) are triclinic, with a 9.1930(7),
b 14.2718(8), c 14.6219(9)
Å, α 106.816(5), β 95.902(5), γ 96.350(5)°,
Z 4, space group P–1.
Condensation of 2-pyridinecarboxaldehydes with 2-, 3-, and 4-H2NC6H4Bpin (pin = 1,2-O2C2Me4) gave the corresponding boron-containing pyridinecarboxaldimines (NNBpin). Addition of these ligands to [PtCl2(coe)]2 (coe = cis-cyclooctene) gave complexes of the type cis-PtCl2(NNBpin) in moderate yields. The platinum complexes have been examined for their potential cytotoxicities against OV2008 (human ovarian carcinoma) and the analogous cisplatin-resistant cell line C13. Key words: boronate esters, pyridinecarboxaldimines, cytotoxicity, platinum, boron.
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