This study reports the relation between scores on psychological tests and subsequent law enforcement officer performance. Sixty-nine officers were administered the Inwald Personality Inventory (IPI; R. Inwald, H. Knatz, & L. Shusman, 1983) and the Minnesota Multiphasic Personality Inventory (MMPI; W. G. Dahlstrom, G. S. Welsh, & L. E. Dahlstrom, 1972) while in training. One year later, subjective and objective job performance data were collected. Analyses indicated that the subjective and some of the objective indicators of performance were related to both MMPI and IPI subscales; the IPI subscales generally exhibited stronger relations. These results suggest that psychological functioning as measured by these personality inventories may be useful for identifying potential officers who will evidence poorer job performance.
Purpose:
Neurodevelopmental disorders (NDDs) encompass a spectrum of genetically heterogeneous disorders with features that commonly include developmental delay, intellectual disability, and autism spectrum disorders. We sought to delineate the molecular and phenotypic spectrum of a novel neurodevelopmental disorder caused by variants in the
GNAI1
gene.
Methods:
Through large cohort trio-based exome sequencing and international data-sharing, we identified 24 unrelated individuals with NDD phenotypes and a variant in
GNAI1,
which encodes the inhibitory Gαi1 subunit of heterotrimeric G-proteins. We collected detailed genotype and phenotype information for each affected individual.
Results:
We identified 16 unique variants in
GNAI1
in 24 affected individuals; 23 occurred
de novo
and one was inherited from a mosaic parent. Most affected individuals have a severe neurodevelopmental disorder. Core features include global developmental delay, intellectual disability, hypotonia, and epilepsy.
Conclusion:
This collaboration establishes
GNAI1
variants as a cause of NDDs.
GNAI1
-related NDD is most often characterized by severe to profound delays, hypotonia, epilepsy that ranges from self-limiting to intractable, behavior problems, and variable mild dysmorphic features.
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