Using published guidelines, 29% of female collegiate athletes in this study were classified into moderate- or high-risk categories using the Female Athlete Triad Cumulative Risk Assessment Score. Moderate- and high-risk athletes were more likely to subsequently sustain a BSI; most BSIs were sustained by cross-country runners.

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Menstrual irregularity is a common occurrence during adolescence, especially within the first 2-3 years after menarche. Prolonged amenorrhea, however, is not normal and can be associated with significant medical morbidity, which differs depending on whether the adolescent is estrogen-deficient or estrogen-replete. Estrogen-deficient amenorrhea is associated with reduced bone mineral density and increased fracture risk, while estrogen-replete amenorrhea can lead to dysfunctional uterine bleeding in the short term and predispose to endometrial carcinoma in the long term. In both situations, appropriate intervention can reduce morbidity. Old paradigms of whom to evaluate for amenorrhea have been challenged by recent research that provides a better understanding of the normal menstrual cycle and its variability. Hypothalamic amenorrhea is the most prevalent cause of amenorrhea in the adolescent age group, followed by polycystic ovary syndrome. In anorexia nervosa, exercise-induced amenorrhea, and amenorrhea associated with chronic illness, an energy deficit results in suppression of hypothalamic secretion of GnRH, mediated in part by leptin. Administration of recombinant leptin to women with hypothalamic amenorrhea has been shown to restore LH pulsatility and ovulatory menstrual cycles. The use of recombinant leptin may improve our understanding of the pathophysiology of hypothalamic amenorrhea in adolescents and may also have therapeutic possibilities.

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Abstrmt-Mobile robot reliability must be guaranteed before they can be employed in hazardous domains like mine clearing or nuclear waste handling, but recent studies of robots used in urban search and rescue and military scenarios have shown a mean time between failures (MTBF) in the field of 6 to 20 hours. This paper extends previous work characterizing robot failures by including recent data and organizing failures according to a novel taxonomy which includes human failures. Failure type and frequency data were collected from 15 robots representing three manufacturers and seven models over a period of three years, in a variety of environments. Standard manufacturing measures for product reliability were used. The results show that overall MTBF and availability have improved since the previous analysis but are still low. The MTBF across all robot types was 24 hours and availability was 54%. The control system was the most common source of failures (32 %), followed by the mechanical platform. Statistical analysis shows that the time between failures, time to repair, and downtime vary widely. For this reason the means reported here are not reliable predictors for future failures, but still provide information on the overall frequency and consequences of mobile robot failures.

Gravin, a multivalent A-kinase anchoring protein (AKAP), localizes to the cell periphery in several cell types and is postulated to target PKA and other binding partners to the plasma membrane. An N-terminal myristoylation sequence and three regions rich in basic amino acids are proposed to mediate this localization. Reports indicating that phorbol ester affects the distribution of SSeCKS, the rat orthologue of gravin, further suggest that PKC may also regulate the subcellular distribution of gravin, which in turn may affect PKA distribution. In this study, quantitative confocal microscopy of cells expressing full-length and mutant gravin-EGFP constructs lacking the proposed targeting domains revealed that either the N-myristoylation site or the polybasic regions were sufficient to target gravin to the cell periphery. Moreover, phorbol ester treatment induced redistribution of gravin-EGFP from the cell periphery to a juxtanuclear vesicular compartment, but this required the presence of the N-myristoylation site. Confocal microscopy further revealed that not only did gravin-EGFP target a PKA RII-ECFP construct to the cell periphery, but PKC activation resulted in redistribution of the gravin and PKA constructs to the same subcellular site. It is postulated that this dynamic response by gravin to PKC activity may mediate PKC dependent control of PKA activity.

Abslmef-Failure data on mobile robots is critical for three reasons: to support the theory of autonomous fault detection, identilication, and recovery necessary for success in new domains; provide design and manufacturing feedhack to the robotics community; and permit project managers to accurately create development schedules. The failures considered in this paper occurred over a period of 2 years, in a variety of environments. Failure type and frequency data were collected from thirteen robots representing three manufacturers and seven models. The data was analyzed using standard manufacturing measures for the reliability of a product. The mean time between failures represents the average time to the next failnre.Avuifabilify was used to gauge the impact of a failure on a project. The results show that the reliability for mobile robots is low, with an average MTBF of 8 hours and availability of less than 50%. The platform itself was the source of most failures (42%) for field robots, while the control system was responsible for 29% of the failures.

Both sport type and Triad risk factors influence BMD. Athletes in low-impact and nonimpact sports and athletes with low BMI and oligomenorrhea/amenorrhea are at highest risk for reduced BMD.