Background: Research education and opportunities are an important part of undergraduate medical education. This study's objectives were to determine students' interest in research, student self-rated research skills, and to assess potential predictors of research interest and confidence.Methods: Stakeholder consultation and literature informed a 13-item cross-sectional survey. In 2014, all students enrolled in McMaster University's School of Medicine in Ontario, Canada were sent an electronic survey and two subsequent reminder e-mails. Results:The response rate was 81% (498 of 618). Most (n=445, 89%) had prior research experiences. The majority of students (n=383, 86%) wanted more research education and opportunities. Higher rating of their supervisors' understanding of research was associated with greater interest in research (OR=2.08; 95% CI=1.27-3.41). Home campus (distributed vs. main) was not a significant predictor of research interest. In our adjusted linear regression model, the most significant predictors of higher self-rated research ability were prior thesis work and other prior research experience. Conclusion:In a survey of a three-year medical school, medical student interest in further research education and opportunities was high and positively predicted by student-rated supervisors' understanding of research, but not campus location. This study also identified several predictors of student self-rated research ability.

To synthesize the available evidence examining the efficacy and safety of levetiracetam compared with phenytoin or fosphenytoin in benzodiazepine-refractory pediatric status epilepticus. DATA SOURCES:We searched (from inception until April 27, 2020) Ovid MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials.STUDY SELECTION: Two reviewers, independently and in duplicate, screened citations and manuscripts for eligible randomized controlled trials. DATA EXTRACTION AND SYNTHESIS:Independently and in duplicate, we performed data abstraction, risk of bias assessment, and certainty assessment using Grading of Recommendations, Assessment, Development, and Evaluation. We performed meta-analyses using randomeffect models or, if insufficient data, presented findings narratively. RESULTS:We identified seven randomized controlled trials (n = 1,575). Pooled analysis demonstrated low certainty evidence for no difference of levetiracetam on time to seizure cessation (mean difference, -3.11 min; 95% CI, -6.67 to 0.45), early seizure cessation (relative risk, 1.09, 95% CI, 0.95-1.26), or late seizure cessation (relative risk, 1.05; 95% CI, 0.93-1.18). Adverse event outcomes were limited by low event numbers. We found low certainty evidence for less respiratory depression with levetiracetam (relative risk, 0.28; 95% CI, 0.12-0.69). CONCLUSIONS:The efficacy of levetiracetam is comparable with phenytoin or fosphenytoin in children with benzodiazepine-refractory status epilepticus (low certainty evidence). Levetiracetam may cause less respiratory depression. Clinicians and guideline developers should weigh safety profiles when choosing between these agents.

OBJECTIVES: Mortality risk stratification may identify a subset of children who benefit from or are harmed by corticosteroid administration. The Pediatric Sepsis Biomarker Risk Model (PERSEVERE)-II score is a biomarker-based mortality risk stratification tool for pediatric sepsis. Our objective was to assess the association of corticosteroid administration with 28-day mortality within different levels of baseline mortality risk (PERSEVERE-II) in a cohort of children with septic shock. DESIGN:We performed a secondary analysis using prospectively collected data (January 2015 to December 2018).

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