Background: Xanthogranulomatous mastitis is an extremely rare condition that is characterised by the infiltration of the breast parenchyma by foamy histiocytes. There have been only 26 reported cases amongst 10 publications. The clinical and radiological presentation of xanthogranulomatous mastitis often causes diagnostic confusion due to its similarity to breast cancer and other forms of chronic inflammatory mastitis.A histological diagnosis is often required either by core needle biopsy or excisional biopsy. Upon review of the literature, surgical excision was the most predominant mode of management.Case Description: We present a case of xanthogranulomatous mastitis in a 40-year-old female who presented with clinical and radiological features of breast malignancy. This was a significantly large mass with a dimension of 90.7 mm by 36.4 mm, which if surgically excised, would have led to permanent cosmetic changes. Multiple core needle biopsies were completed to consider other differentials of histiocytic lesions including cystic neutrophilic granulomatous mastitis, histiocytoid lobular breast carcinoma, Rosai-Dorfman disease and Erdheim-Chester disease.
Conclusion:Clinical improvement was noted with reduction in size from prolonged antibiotic therapy suggesting an initial conservative approach in the management of xanthogranulomatous mastitis. By contributing our experience with xanthogranulomatous mastitis, we also present a review of literature on its aetiology, clinical features, and management of this pathology.
Acute acalculous cholecystitis is an uncommon disease in children and is usually associated with trauma, burns, and infections. Whereas acute acalculous cholecystitis is only seen in 10% of cholecystitis in adults, it is uncommon in the paediatric population.A seven-year-old male presented to the emergency department of a regional hospital with a 36-hour history of right-upper-quadrant abdominal pain. He had associated symptoms of anorexia, nausea, and vomiting. He was septic with raised white cell count and inflammatory markers. Diffuse gallbladder wall thickening without intraluminal sludge or calculi was seen on abdominal ultrasound. He was found to have a concurrent right-upper lobe pneumonia on further investigation. The patient was treated with antibiotics and responded well to supportive and conservative management with close radiological monitoring.Acute acalculous cholecystitis is associated with a high mortality rate (30%) and significant complications such as gangrene, empyema, and perforation in 40% of adult cases. Acute surgical management has been traditionally advocated, however, surgery is not without risks; studies have suggested that non-operative intervention may be appropriate for selected critically ill children with an underlying cause.Herein, we discuss the safe and effective conservative treatment of acute acalculous cholecystitis in lieu of operative management and highlight the importance of recognising this disease in paediatric patients with acute abdominal pain and coexisting infection.
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