Objective
Bulimia nervosa (BN) has been characterized as similar to an addiction, though the empirical support for this characterization is limited. This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN.
Method
PET imaging with [11C]raclopride, pre/post methylphenidate administration, to assess dopamine type 2 (D2) receptor binding (BPND) and striatal DA release (ΔBPND).
Results
There was a trend towards lower D2 receptor BPND in two striatal subregions in the patient group compared to the control group. DA release in the putamen in the patient group was significantly reduced and, overall, there was a trend towards a difference in striatal DA release. Striatal DA release was significantly associated with the frequency of binge eating.
Discussion
These data suggest that BN is characterized by abnormalities in brain DA that resemble, in some ways, those described in addictive disorders.
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