Population-based data reveal significant disparities in screening indications for PNDx and hence, in diagnostic yield, according to socioeconomic region. This finding may have ethical and policy implications for prenatal screening in Australia.
Conclusions:In this first randomised study of cfDNA testing vs. first trimester combined screening we demonstrate that even after exclusion of cases with increased NT or fetal anomalies and using the same risk cut-off of 1:100, the combination of first trimester ultrasound and cfDNA testing results in significantly lower false positive cases than first trimester combined screening.
OC15.04Chromosomal abnormalities detected by cell-free DNA testing as a contingent approach versus direct invasive prenatal diagnosis
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