Background/Aim. Haemoglobin determination is a routine part of the blood donor selection process. Previously reported studies have revealed that iron deficiency is common in frequent donors. This prospective investigation was aimed at examining iron status among blood donors with low circulating haemoglobin and evaluating capillary methods for haemoglobin determination in relation to reference values from venous blood count (BC) and ferritin level. Methods. Between February 2017 and December 2018, 200 consecutively recruited regular blood donors with low haemoglobin, aged 19 to 64 years (median 39) were included. Haemoglobin was determined using copper sulphate and HemoCue capillary methods as well as in venous blood samples on a haematology analyzer. Plasma ferritin was determined turbidimetrically. Results. In 42.7% of the men and 57.3% of the women ferritin concentration was low (P = 0.008). The relative numbers of males and females with levels <12 μg/L (P=0.023) or >50 μg/L (P=0.022) differed. Comparison of the values obtained with the capillary methods with reference haemoglobin obtained from the blood count (BC) showed that the copper sulphate procedure gave false fails in 10.5% cases (P<0.001). Values from HemoCue were significantly correlated with haemoglobin from BC, but no correlation was observed between ferritin levels and either capillary method. Conclusion. In 51.5% of Serbian blood donors referred due to low haemoglobin a low ferritin was observed. Based on our study results the determination of the algorithm in the iron deficiency detection is necessary, while capillary method (HemoCue) represents more convenient method for haemoglobin testing prior to donation.
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