Cancer immunoresistance and immune escape may play important roles in tumor progression and pose obstacles for immunotherapy. Expression of the immunosuppressive protein B7 homolog 1 (B7-H1), also known as programmed death ligand-1 (PD-L1), is increased in many pathological conditions, including cancer. Here we show that expression of the gene encoding B7-H1 increases post transcriptionally in human glioma after loss of phosphatase and tensin homolog (PTEN) and activation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. Tumor specimens from individuals with glioblastoma multiforme (GBM) had levels of B7-H1 protein that correlated with PTEN loss, and tumor-specific T cells lysed human glioma targets expressing wild-type PTEN more effectively than those expressing mutant PTEN. These data identify a previously unrecognized mechanism linking loss of the tumor suppressor PTEN with immunoresistance, mediated in part by B7-H1.

[1] A variety of formulae has been developed to predict bed load transport in gravel bed rivers, ranging from simple regressions to complex multiparameter formulations. The ability to test these formulae across numerous field sites has, until recently, been hampered by a paucity of bed load transport data for gravel bed rivers. We use 2104 bed load transport observations in 24 gravel bed rivers in Idaho to assess the performance of eight different formulations of four bed load transport equations. Results show substantial differences in performance but no consistent relationship between formula performance and degree of calibration or complexity. However, formulae containing a transport threshold typically exhibit poor performance. Furthermore, we find that the transport data are best described by a simple power function of discharge. From this we propose a new bed load transport equation and identify channel and watershed characteristics that control the exponent and coefficient of the proposed power function. We find that the exponent is principally a factor of supply-related channel armoring (transport capacity in excess of sediment supply), whereas the coefficient is related to drainage area (a surrogate for absolute sediment supply). We evaluate the accuracy of the proposed power function at 17 independent test sites.

You may order additional copies of this publication by sending your mailing information in label form through one of the following media. Please specify the publication title and series number. AbstractThis report and associated web site files provide sediment transport and related data for coarse-bed streams and rivers to potential users. Information on bedload and suspended sediment transport, streamflow, channel geometry, channel bed material, floodplain material, and large particle transport is provided for 33 study reaches in Idaho that represent a wide range of drainage areas, average annual streamflows, channel gradients, and substrate sizes. All the study reaches have a coarser layer of surface bed material overlaying finer subsurface material.Both bedload and suspended sediment transport increase with discharge and the relationship can be reasonably represented using a log-log model. At most sites, the suspended load makes up the majority of the total sediment load. The size of the largest bedload particle in transport and usually the median size of the bedload increase with discharge. However, the median size of the bedload is much smaller than the channel surface material and sand is the primary or a large component of the bedload material.A large proportion of the annual sediment production occurs at the higher streamflows during snowmelt. On average, discharges equal to or larger than bankfull occur 3.3 percent of the time and transport 61.5 percent of the annual bedload sediment. Discharges less than the average annual discharge, on average, occur 75.0 percent of the time and transport about 3.8 percent of the annual bedload sediment.

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The use of 2 surgeons at an experienced spine deformity center decreases the operative time and estimated blood loss, and may be a key factor in witnessed decreased major complication prevalence. This approach also may decrease the rate of premature case termination and return to operating room in 30 days.

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