The DAVID gene functional classification tool uses a novel fuzzy clustering algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules.

ILITARY PERSONNEL ARE prone to outbreaks of respiratory illness such as influenza for a variety of reasons, including crowding and stressful conditions. 1-3 Before the availability of an influenza vaccine, the military population experienced high mortality and morbidity during such outbreaks. Trivalent inactivated vaccine (TIV), administered intramuscularly, was first developed and tested in the military in the 1940s and has been used annually since the 1950s to prevent influenza and its complications. 4 In 2003, a live attenuated influenza vaccine (LAIV) with the same antigenic characteristics as TIV was formulated for intranasal application and approved for use among healthy adults. Service members were immediately targeted for LAIV use by the US Department of Defense (DOD) because of the ease of vaccine administration and availability early in the season. During the TIV vaccine shortage in 2004, the DOD agreed to preferentially use LAIV to increase the availability of TIV. 5 Although TIV remained the predominant vaccine until the 2006-2007 season, LAIV has increasingly become the preferred vaccine for service members while TIV is reserved for those with higher risk for respiratory diseases or contraindications to LAIV. 6,7 Recent clinical trials comparing LAIV with TIV suggest that LAIV has superior efficacy over TIV among young

We previously reported that lentiviral vectors derived from the simian immunodeficiency virus (SIV) were efficient at transducing rhesus hematopoietic repopulating cells. To evaluate the persistence of vector-containing and -expressing cells long term, and the safety implications of SIV lentiviral vector-mediated gene transfer, we followed 3 rhesus macaques for more than 4 years after transplantation with transduced CD34 ؉ cells.