No abstract

Positive associations were observed for anorectal atresia, esophageal atresia, and omphalocele and maternal periconceptional asthma medication use, but not for other defects studied. It is possible that observed associations may be chance findings or may be a result of maternal asthma severity and related hypoxia rather than medication use.

The objective of this study was to examine the association between maternal asthma medication use during the periconceptional period and the risk of gastroschisis. In this case-control study, the authors used data on deliveries enrolled in the National Birth Defects Prevention Study (1997-2002) from eight collaborating centers. The cases included 381 infants with isolated gastroschisis, and the controls were 4,121 liveborn infants without malformations. The asthma medications used during the periconceptional period (1 month prepregnancy through the third pregnancy month) were divided into two groups, antiinflammatory and bronchodilator, and analyzed separately. Users of multiple asthma medications during the periconceptional period were also examined. Logistic regression was used to estimate odds ratios and 95% confidence intervals while controlling for maternal age, race/ethnicity, education, smoking, folic acid/vitamin use, and other vasoactive medications. Maternal bronchodilator use showed an elevated statistically significant risk of gastroschisis (adjusted odds ratio = 2.06, 95% confidence interval: 1.19, 3.59). No significant association was found between maternal use of asthma antiinflammatory medications and gastroschisis. Because information on maternal asthma status/severity was not available, the effects of disease on the risk of gastroschisis cannot be ruled out. Additional research is needed in determining whether a real risk exists and for guiding asthma treatment.

This study examined the geographic distribution of asthma hospitalizations in New York State (NYS) and its association with socioeconomic status. Statewide asthma hospitalization data (1987-1993) were merged with 1990 census data by residential zip code. The asthma hospitalization rate increased in NYS from 1987 (2.54 per 1000) through 1993 (2.87 per 1000) and the increase is largely attributable to increases for children 4 years old and younger. The risk factors for asthma admission varied in different areas. However, rates of hospitalization because of asthma were generally higher in the zip codes areas with higher proportions of poverty, unemployment, poorly educated residents, African-Americans, and Hispanics.

This study examined whether racial/ethnic minority (i.e., Black, Hispanic) children with wheeze have a higher proportion of urgent care use (i.e., emergency department visit or hospitalization) for asthma compared to their White counterparts. We also assessed the contribution of disease severity and sociodemographic, access to care, and home environmental risk factors to racial/ethnic differences in utilization. A cross-sectional study was conducted among children aged 0 to 17 in Buffalo, New York. We compared rates of urgent care visits and physician-diagnosed asthma among racial/ethnic groups, and conducted race/ethnicity stratified analyses by number of symptoms, asthma severity, insurance types, and medical care access. Multivariate regression analyses were used to examine differences in urgent care use by race/ethnicity after controlling for multiple confounders and to identify factors associated with urgent care utilization by race/ethnicity. Asthma symptom severity was the primary factor contributing to urgent care use in this population, followed by race/ethnicity and Medicaid enrollment. Minority children with wheeze were nearly twice as likely as Whites to have used urgent care for asthma, after controlling for disease severity, access to care, and environmental factors. Not having a home remedy in place for asthma or reporting trouble getting care also contributed to the greater use of urgent care resources among minority children. Minority children still had a significantly higher proportion of urgent care use for acute asthma care compared to Whites, even after controlling for multiple risk factors. Disease severity and inadequate access to medical care may partially explain higher rates among minority children. Future studies should examine racial/ethnic differences in other factors potentially associated with urgent care use, including asthma management and use of routine asthma care.

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We present prevalence estimates of indoor and outdoor environmental risk factors for asthma from a cross-sectional study of children 1 to 17 years of age living in Buffalo, New York. A child's primary caretaker completed a questionnaire about the household's demographics, lifestyle habits, housing, indoor and outdoor environment, and the child's activity patterns, family history of asthma, asthma symptoms and treatment, and medical care access. Significant environmental risk factors were presence of smokers in the household, humidifier or vaporizer use, chemical odors indoors, frequent truck traffic, and chemical odors outdoors. Most of these risk factors can be mitigated or controlled.

There is the suggestion that residential proximity to some airports may increase hospital admissions for respiratory disorders. However, there are many factors that could influence this association that may differ by airport, which should be measured and studied further.