These results suggest that gastrin (and perhaps CCK that belongs to the same peptide family) may play a role in the growth of a substantial proportion of human astrocytic tumors.
There are few papers in existence describing the histopathology of Kashin-Beck disease. The few existing papers mention chondronecrosis within the epiphyseal primodium and metaphyseal cartilage. In the present study, two series of samples were available for histology: supernumerary fingers removed from young subjects and intra-articular bodies collected in more advanced cases of the disease. The prevailing characteristic of the samples is the absence of vascularisation within the proximal cartilage end plate of the phalanx associated with an alteration of the epiphyseal bone formation. These observations suggest that Kashin-Beck disease could develop from an alteration of the angiogenesis of the metaphyseal cartilage resulting in degeneration with consequent joint dysplasia, which may be associated with a decrease in growth of the diaphyseal bones.Résumé Très peu de publications décrivent l'histopathologie de la maladie de Kashin-Beck. Elles mentionnent essentiellement la présence de nécroses des chondrocytes au sein des cartilages métaphysaires et articulaires. Dans notre étude, un examen histologique a été réa-lisé sur deux types de prélèvements: des doigts surnumé-raires provenant de trois sujets jeunes et des souris articulaires provenant de cas plus âgés. La caractéristique la plus marquante est l'absence de vascularisation de la couche terminale du cartilage épiphysométaphysaire des phalanges entraînant une perturbation de l'ossification épiphysaire. Ces observations suggèrent que les manifestations cliniques de la maladie de Kashin-Beck soient dues à un trouble de l'angiogénèse au niveau du cartilage métaphysaire entraînant sa dégénérescence et secondairement des dysplasies articulaires associées ou non à une diminution de la croissance de la diaphyse des os longs.
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