Studies on seventy-five sera containing antibodies of the H‘0’I-B complex
together with a survey of studies by other workers show that many of the
antibodies formerly called anti-‘0’ and some of those called anti-H are in fact
reacting with a joint product of the H and I genes.
The serological specificities of these antibodies were shown by agglutination
tests with cells of known H and I or B and I status, together with the use of neutralisation
and absorption techniques. These tests revealed that many of the sera
contain mixtures of antibody specificities.
The occurrence of anti-H-HI antibodies is probably associated with pregnancy.
An H notation based on that proposed by Wiener et al. is recommended for
use in the classification of these antibodies.
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