Electrochemical reduction of diazonium salts and oxidation of carboxylates on high surface felt electrodes
permits functionalization of the surface of the felt. The functionalization has been ascertained by different
methods including elemental analysis, X-ray photoelectron spectroscopy, scanning microscopy/energy-dispersive spectrometry, and IR spectroscopy. The loadings which are obtained are of the same order of
magnitude as those of commercial ion-exchange resins or of resins used for combinatorial chemistry.
It is possible to prepare carbon-based analogues of the Merrifield resin by electrochemical reduction of diazonium salts or oxidation of aryl acetates on high specific surface area carbon felts. These modified felts can undergo further reactions: nucleophilic substitution, Suzuki reaction, and finally reductive electrochemical cleavage, taking advantage of the conductivity of the carbon felt. This provides a simple example of the possible use of electrochemistry in combinatorial synthesis.
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