The synthesis of 2',3' asymmetrically substituted pyrimidine ribonucleosides in 70-95% yields by using modified Verbruggen conditions with "nonparticipating" 2-0-CH3 and 2-O-TBDMS ribofuranoses is described. Such compounds are useful synthons for oligoribonucleotide synthesis, including incorporation of "rare" bases. New and practically useful conditions for placement (using 1,2,4-triazole) and removal (KF/crown ether) of the teri-butyldimethylsilyl (TBDMS) protecting group are also reported.
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