The most important scale-up parameters of aerated bioreactors are investigated in 42 and 340 L vessels, with water and various xanthan gum and carboxymethyl cellulose solutions. The study focuses mainly on mass transfer (k L a) measurements under various operating conditions. The relevance of existing correlations is discussed. The traditional viscosity-contribution approach appears unable to predict the changes in k L a during scale-up and an alternative formulation is proposed. The effect of rheology on power consumption and mixing time is in fair agreement with works published on this topic.
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