Chronic myelomonocytic leukemia (CMML)is a clonal hematopoietic disorder that occurs in elderly patients. One of the main diagnostic criteria is the accumulation of heterogeneous monocytes in the peripheral blood. We further explored this cellular heterogeneity and observed that part of the leukemic clone in the peripheral blood was made of immature dysplastic granulocytes with a CD14 ؊ /CD24 ؉ phenotype. The proteome profile of these cells is dramatically distinct from that of CD14 ؉ /CD24 ؊ monocytes from CMML pa-
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