Hypothyroidism significantly increases the slope of the dose response line obtained by the subcutaneous and intravaginal administration of oestrone and concomitantly decreases the M.E.D. Hyperthyroidism has the reverse effect. Hypothyroidism, however, has no influence on the dose response line obtained by the intravaginal administration of oestradiol-S,17(J.
The optimum conditions for the intravaginal administration of oestrogens are obtained by the use of 1 per cent. aqueous egg albumin as solvent, and two or four injections spread over 24-86 hr. The administration of oestrone, oestradiol-8,17,B, and diethylstilboestrol in distilled water by four injections in 86 hr gives a close approximation to, the optimum. Oestriol, however, has considerably reduced activity when administered under these conditions.
(i) 'rho subcutaneous or intravaginal administration of oestrone to the ovariectomized monso causes an increase in the dry weight of the vagina with a maximum at full keratinization. ~rhe water content of the tissue is increased in the pre-keratinization phase, and reduced in the keratinization phase. 'rhe true glycogen content, of the vagina does not, increase until keratinization eommenees.
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