Member of a globalized economy focused on innovation, the ABC region of São Paulo state represents an important pole of national economic development. With a strong industrial presence and a relevant role in the production of goods and services, the region has important research, development and innovation (R&DI) hubs, including universities and governmental / industrial support agencies. Although there are incentives for the development of new technologies in basic research, insufficient effort has been done to foster innovative research and development projects in the stage of scheduling (TRL4 +). Based on the concepts of the triple helix, this research had the objective of evaluating the cooperation models existing in 13 companies that worked in the development of new technologies and presented interruptions in the development of their R&DI projects. The selection of the participating companies was made by the adequacy to the theme, availability and adoption of development and innovation practices. The method was applied through the application of a semi-structured questionnaire, the use of interviews to deepen the data collected in the first phase, at the same time, interviews were made with regional development agencies, including economic development secretariats of the municipal government. An analysis of existing and in development innovation incentive programs and their possible adaptation to the studied research problem was carried out. The results of the present research point to the existence of the so-called death valley of scientific research (TRL4 +) in the region, pointing out as one of the main causes for this fact, the inherent costs of acquiring and maintaining a scientific research infrastructure in micro and small enterprises (MSE) analyzed. The research points to the need to review the existing models of cooperation and development of new technologies, positioning the sharing of R&DI infrastructures in phase TRL4+ as a possible solution to strengthen the regional and national economy and increase the efficiency of research conversion rates technologies for the market.
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