Objective:The present study was designed to evaluate the effect of Aegle marmelos unripe fruit extract (AMFE) on inflammatory bowel disease (IBD) in Wistar albino rats.Materials and Methods:Effect of AMFE was studied on acetic acid induced ulcerative colitis (1 ml of 4% acetic acid solution, transrectal) and indomethacin-induced enterocolitis (10 mg/kg, single dose, p.o) in Wistar albino rats. The extract was administered orally at different dose of 150, 200 and 250 mg/kg body weight. Disease pathogenesis was assessed by measuring disease activity index (DAI), macroscopic score, microscopic score, mesenteric mast cell protection, superoxide dismutase (SOD), and malonaldehyde (MDA) levels in the above two models.Results:The results showed a dose dependent decrease in intestinal inflammation following treatment with AMFE. Significant protection in mast cell degranulation was observed in acetic acid and indomethacin-induced IBD models. Treatment with AMFE significantly decreased the MDA levels and increased SOD activity.Conclusion:In our study, AMFE produced anti-inflammatory, antioxidant, and mast cell stabilizing effects demonstrating protective effect in inflammatory bowel disease.
Context: Prolonged use of hypoglycaemic drugs is problematic due to their toxic side effects and diminution of response. Oral antihyperglycaemic agents from plant sources are therefore being explored for use in traditional medicine. Aims: To study antihyperglycaemic, hypolipidemic and antioxidant effect of aqueous extract of Triticum aestivum grass (TAGE) in two different models of T2DM in wistar albino rats such as High Fat Diet with Low dose STZ and High Fructose Diet models. Settings and Design: Two models of insulin resistance were used (single i.p injection of STZ (45 mg/kg) with high fat diet and fructose 10% w/v, p.o, ad libitum). Methods and Material: STZ with high fat diet and fructose 10% w/v, p.o, in rats was administered for a period of 21 days. Three doses of TAGE (40, 60 and 80 mg/kg, p.o) were used. Pioglitazone (PG) 20 mg/kg was used as the reference standard. At the end of the experimental period, serum biochemical parameters like fasting blood sugar, plasma insulin, lipid profile and MDA and SOD activity were studied in both the models. Statistical analysis used: one way ANOVA followed by Turkey's multiple comparison test. p<0.05 was considered as significant. Results: In both the models, TAGE significantly lowered plasma glucose, lipid, MDA level and increased SOD activity. It also improved insulin resistance which is comparable to that of normal and standard group. Conclusion: TAGE may be a potent drug, for treatment and prevention of complications of T2DM used alone or in combination with other oral hypoglycaemic agents.
Background: Diabetes mellitus is a common chronic disease. One of the pathophysiology is found to be oxidative stress. This study aims to evaluate the effect of resveratrol on oxidative stress in high fat diet (HFD)/streptozotocin induced diabetic rats.Methods: Wistar albino rats, fed with HFD rendered diabetic with streptozotocin, were divided into 6 groups, namely the diabetic control treated with vehicle (DC), standard control which received metformin (SC), test groups treated with 5,10, and 20 mg/kg b.w. of resveratrol and combination of half dose of metformin and resveratrol (10 mg/kg)(TC). A group of six normal animals served as normal control (NC), another six as HFD control. Fasting blood glucose, lipid profile and serum MDA and SOD were measured one week after induction of diabetes. The animals were then treated orally for 2 weeks after which the same parameters were repeated. The in-vivo results were analysed by one way ANOVA followed by Tukey’s multiple comparison test.Results: The DC group demonstrated a increase in the fasting blood glucose compared to NC, HFD control while a significant decrease in the fasting blood glucose was observed with SC, Test groups (p<0.05) as compared to the DC group. TC showed a significant improvement in dyslipidemia compared to their baseline values (p<0.05). There was significant change in the serum MDA level and SOD activity.Conclusions: Resveratrol improves oxidative stress in diabetic rats.
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