<p><em>Pleroma urvilleanum (Clidemia hirta) is a plant that is widely found in Maluku, which contains chemical compounds, including tannins (catechols and pyrogalotanins), dioxyanthraquinones, steroids, saponins, glycosides and phenols which of these contents can function as antibacterial. This study aimed to determine the antibacterial activity of the ethanol extract of Pleroma urvilleanum(Clidemia hirta) leaf from Maluku with various concentrations of 5%, 25%, 50% and 75% against the growth of Staphylococcus aureus bacteria. The research design used is an experimental laboratory using the agar diffusion method by means of wells. The results of the study showed that at a concentration of 5%, it has an inhibitory power of 20 mm with a strong category. While at a concentration of 25% it has an inhibitory power of 29 mm, at a concentration of 50% it has an inhibitory power of 34 mm and at a concentration of 75% has an inhibitory power of 35 mm with a very strong category. Conclusion: ethanol extract Pleroma urvilleanum (Clidemia hirta) leaf from Maluku has antibacterial activity against the growth of Staphylococcus aureus bacteria and the higher the concentration, the greater the antibacterial activity.</em></p><p><em>Keywords: Antibacterial activity</em>, <em>Harendong bulu (Clidemia hirta)</em>, <em>Staphylococcus aureus, Moluccas</em></p>
The use of natural ingredients as traditional medicine with better use is now more in demand. This is because traditional medicine is relatively easy to obtain. One type of medicinal plant that is often used by the community is (Annona mucirata L). or better known as soursop. Soursop leaves (Anonna mucirata L.) have been widely used as a medicinal ingredient because it contains tannin and flavanoid compounds which can provide antibacterial effects. The purpose of this study was to determine the content of the compounds contained in soursop leaves (Anonna mucirata L.) and to formulate an ethanol extract ointment of soursop leaves (Anonna mucirata L.) with various ointment bases. This research was conducted using an experimental method in which evaluations of the ointment were carried out including the organoleptic test, pH test and homogeneity test. The results showed that ethanol extract of soursop leaves (Anonna mucirata L.) containing tannins and flavonoids. The results of the ointment formulation on the hydrocarbon base formulation, the absorption base formulation and the water soluble base formulation resulted in physical differences in the organoleptic test, but did not have different results on the homogeneity test and pH test. In conclusion, extract ethanol of soursop (Anonna mucirata L.) leaf contains tannin and flavanoid compounds. The ethanol extract ointment of soursop leaves (Anonna mucirata L.) with variations of FI (hydrocarbon base) and FII (absorption base) ointment has good ointment properties, while FIII (water-soluble base) does not have good physical properties because it has a dosage form which is liquid and smells rancid based on the organoleptic test. The ethanol extract ointment of soursop leaves (Anonna mucirata L.) with variations of FI (hydrocarbon base) and FII (absorption base) ointment has good ointment properties, while FIII (water-soluble base) does not have good physical properties because it has a liquid dosage form and smells rancid based on the organoleptic test. Keywords: ointment extract; soursop plant; ointment base ABSTRAK Pemanfaatan bahan alam sebagai obat tradisional dengan penggunaan yang lebih baik sekarang lebih diminati. Hal ini dikarenkan obat tradisional relatif mudah didapat. Salah satu jenis tanaman obat yang sering dimanfaatkan oleh masyarakat adalah (Annona mucirata L). atau yang lebih di kenal dengan nama sirsak. Tanaman daun sirsak (Anonna mucirata L.) sudah banyak digunakan sebagai bahan obat karena mengandung senyawa tannin dan flavanoid yang mampu memberikan efek antibakteri. Tujuan penelitian ini untuk mengetahui kandungan senyawa yang terdapat pada daun sirsak (Anonna mucirata L.) serta membuat formulasi sediaan salep esktrak etanol daun sirsak (Anonna mucirata L.) dengan variasi basis salep. Penelitian ini dilakukan dengan menggunakan metode experimental dimana dilakukan evaluasi terhadap salep yang dibuat meliputi uji organoleptik, uji pH dan uji homogenitas. Hasil penelitian ini yaitu ekstrak etanol daun sirsak (Anonna mucirata L.) mengandung senyawa tannin dan flavanoid, untuk hasil formulasi sediaan salep pada formulasi basis hidrokarbon, formulasi basis absorbsi dan formulasi basis larut air menghasilkan perbedaan fisik uji organoleptik, namun tidak memiliki hasil yang berbeda pada uji homogenitas dan uji pH. Dari hasil penelitian dapat disimpulkan yaitu ekstrak estanol daun sirsak (Anonna mucirata L.) mengandung senyawa tannin dan flavanoid. Sediaan salep esktrak etanol daun sirsak (Anonna mucirata L.) dengan variasi basis salep FI (basis hidrokarbon) dan FII (basis absorbsi) memiliki sifat salep yang baik, sedangkan FIII (basis larut air) tidak memiliki sifak fisik yang baik karena memiliki bentuk sediaan yang cair dan bau tengik berdasarkan uji organoleptik. Kata kunci: ekstrak salep; tanaman daun sirsak; basis salep
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