Introduction - Medicinal plants, as well as poisonous plants, have different alkaloid compositions in every season. According to the traditional texts of Ayurveda, Visha Dravya have greater potency in Varsha Ritu, which reduces due to Agasti rising in Sharad Ritu. Objective - To evaluate the potency of Visha in Varsha and Sharad Ritu through estimation of the concentration of Strychnine in Strychnos nux- vomica L. Materials and Methods – Quantitative analysis of Strychnine in Varsha and Sharad Ritu by HPTLC. Results – The concentration of Strychnine was observed higher in Varsha Ritu than in Sharad Ritu. Conclusion – The study confirms that the potency of Visha is greater in Varsha Ritu than in Sharad Ritu.
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