Synthetic DNA-binding
inhibitors capable of gaining precise control
over neurogenesis factors could obviate the current clinical barriers
associated with the use of small molecules in regenerative medicine.
Here, we report the design and bioefficacy of the synthetic ligand
PIP-RBPJ-1, which caused promoter-specific suppression of neurogenesis-associated
HES1 and its downstream genes. Furthermore, PIP-RBPJ-1 alone altered
the neural-system-associated Notch-signaling factors and remarkably
induced neurogenesis with an efficiency that was comparable to that
of a conventional approach.
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