Background: Rhizome of Curcuma longa has many therapeutic implications in traditional Indian medicine. It is used in traditional medicine for flatulence, dyspepsia, and other gastric problems. There is conflicting reports regarding its antiulcer and ulcerogenic potential. Aims and Objectives: The study is with the aim of determining the gastoprotective effect of C. longa extract on aspirin-induced gastric ulcer in rats. Materials and Methods: C. longa rhizomes were collected locally. Preparation of extract was done with 50% ethanol using Soxhlet extraction. Albino rats of Wistar strain were used for the study. Aspirin was purchased from Sigma Labs, Mumbai. Anti-ulcer effect of the extract was studied in rats after inducing mucosal damage by aspirin. Results: It was found that extract of C. longa exhibited significant protection against aspirin-induced ulcer at dose levels of 250-mg/kg, 500-mg/kg, and 1000 mg/kg body weight. There is a dose-dependent increase in the ulcer protective action of the extract. Conclusion: The present study with extract of C. longa revealed its anti-ulcer activity.
Background: Curcuma longa or turmeric is a popular Ayurvedic herb, traditionally used for various inflammatory conditions including rheumatoid arthritis and spondylitis. Turmeric which containing phytochemical ingredient curcumin is used in India for centuries as a topical anti inflammatory agent. Many of the currently used anti inflammatory agents like NSAID’s and glucocorticoids have many undesirable adverse effects, especially when they are used for long period. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its anti-inflammatory effects.Methods: The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxlet extraction with 50% ethanol. Albino rats of Wistar strain (170-250grams) obtained from the animal house of medical college Thiruvananthapuram were used. Aspirin was purchased from sigma Labs, Mumbai. Anti-inflammatory effect of the extract was done in rats by the method of Carrageenin induced paw oedema.Results: The ethanolic extract of Curcuma longa inhibited the development of oedema at the end of 3 hours. The anti-inflammatory activity exhibited by the extract was dose dependent and statistically significant at dose levels of 1000-mg/kg and comparable to that of standard drug used Aspirin.Conclusions: The present study with extract of Curcuma longa revealed that it has significant anti-inflammatory activity.
BACKGROUND Peptic ulcer is a global health problem, both in terms of morbidity and mortality. There are many treatment strategies for tackling this disease including proton pump inhibitors, H2 receptor antagonists, ulceroprotectives like prostaglandin analogues and sucralfate. But they have certain limitations like adverse effects, drug interactions and relapses. Some medicinal plants are found to be effective in treating and preventing peptic ulcer diseases. Scientific evaluation of these herbal extracts with active chemical ingredient can be beneficial to find out newer treatment modalities for peptic ulcer diseases with lesser adverse effects and drug interaction. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its antiulcer properties. MATERIALS AND METHODS This is a Comparative Study. The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxlet extraction with 50% ethanol. Albino rats of Wistar strain (120-200 grams) obtained from the animal house of medical college Thiruvananthapuram were used for the study. Sucralfate was purchased from Sigma Labs, Mumbai. Antiulcer effect of the extract was studied in the rat models, where mucosal damage was induced by ethyl alcohol. RESULTS Extract of Curcuma longa exhibited significant protection against alcohol induced gastric damage at dose levels of 1000 mg/kg body weight comparable to that of standard drug Sucralfate. CONCLUSION The present study with extract of Curcuma longa revealed that it has significant anti-ulcer activity.
INTRODUCTIONPeptic ulcer is a multifactorial disease. Factors like increased stress, impaired mucosal resistance, genetic factors, infection with H. pylori and anti-inflammatory drugs including NSAIDs damage gastric mucosa. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its antiulcer property.Curcuma longa has an important place in the Indian household. It is considered auspicious in all religious observations in Indian households. It is a normal constituent of condiments and curry powders. Curcuma longa, which have a prominent place in Indian system of medicine, have attracted the interests of scientists and were subjected to extensive research.Constituents of Curcuma longa exert several protective effects on the gastrointestinal tract. A salt of curcumin, sodium curcuminate, was found to inhibit intestinal spasm, and p-tolymethylcarbinol, a turmeric component, was found capable of increasing gastrin, secretin, bicarbonate, and pancreatic enzyme secretion.1 . Curcuma powder has been reported to increase gastric wall mucus, in a study conducted by Rafathullah S and coworkers.2 Curcuma powder has been reported to increase the mucin content of gastric juice in rabbits. It may thus be beneficial in protecting the gastric mucosa from irritants.3 By the method of receptor combination, effects of the active constituents in Curcuma longa on gastrin receptor were studied by Xiao X and coworkers. 4 The results showed that Curcuma longa have antagonistic action on gastrin receptor. Mahady GB and coworkers found that methanol extract of Curcuma longa and curcumin inhibit growth of ABSTRACT Background: Substantial part of the world population has been known for a long time to suffer from peptic ulcer disease. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its antiulcer properties. Methods: The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxhlet extraction with 50% ethanol. Albino rats of Wistar strain (120-200 grams) obtained from the animal house of medical college Thiruvananthapuram were used. Ranitidine was collected from Kerala Sate Drugs and Pharmaceutical LTD Alapuzha. Antiulcer study in rats were done using the method of pyloric ligation. Results: Antiulcer study in rats using the method of pyloric ligation, extract of Curcuma longa in 1000mg/Kg dose levels exhibited significant protection against shay ulceration. The results were comparable to that of standard drug Ranitidine. Conclusions:The present study with extract of Curcuma longa revealed that it has significant anti-ulcer activity.
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