No abstract

Age-related macular degeneration (AMD) is a complex and multifactorial disease characterized by the damage of the unit comprised of the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. Although the outer retina appears to be mainly affected in this disorder, several evidences exhibit that also the inner retina may be impaired. In this review we will provide a description of the prominent histologic and imaging findings suggesting an inner retinal loss in these eyes. In details, structural optical coherence tomography (OCT) technology proved either the inner and outer retina is impacted by AMD and that these two impairments are associated. Therefore, the purpose of this review is to provide a description of the role of neurodegeneration in AMD in order to better understand the relationship between neuronal loss and the outer retinal damage in this disease.

Purpose To report the retinal vessel wall changes in a patient with acute branch retinal artery occlusion with fundus fluorescein angiography and adaptive optics imaging. Methods Retrospective, observational case Case description A 49-year-old female with cardiac ailment complained of sudden onset superior field loss for 4 days in her right eye. Her presenting visual acuity in the right eye was 20/20, N6. She was diagnosed with right eye infero-temporal branch retinal artery occlusion. A golden-yellow, round coloured embolus was noted on clinical examination obstructing the temporal division of the inferior branch of central retinal artery. Patient underwent ocular massage, anterior chamber paracentesis and oral Acetazolamide (Tab. Diamox 250 mg QID) medications. Vessel wall changes were noted using fluorescein angiography and adaptive optics retinal imaging at presentation and 10-day follow-up visit. Conclusion This case highlights the importance of multimodal retinal imaging like fluorescein angiography and adaptive optics imaging in identifying and understanding the retinal vessel wall changes in the occluded vascular segment of the retina.