We report the first synthesis of hyperbranched poly(N-(2-hydroxypropyl) methacrylamide) (HB-PHPMA) using reversible addition–fragmentation chain transfer (RAFT) self-condensing vinyl polymerization (SCVP).
The
design and synthesis of a new class of thermally-labile poly(β-thioester)s
is reported. Aliphatic azo linkages were incorporated into the main
chain of the polymers to allow for degradation to lower molecular
weights upon heating. These polymers displayed a temperature-dependent
degradation profile with a significant increase in decomposition rate
as the temperature was raised from 60 to 95 °C. This approach
was further extended to prepare amphiphilic triblock copolymers containing
poly(β-thioester)s and poly(ethylene glycol) (PEG). The resulting
block copolymers were capable of self-assembly into micelles in water.
Moreover, the assembled nanoparticles underwent dissociation as a
result of exposure to heat.
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