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The Barcelona Brain Health Initiative (BBHI) is an ongoing prospective longitudinal study focused on identifying determinants of brain health. The main objectives are: (i) to characterize lifestyle, cognitive, behavioral and environmental markers related to a given individual’s cognitive and mental functions in middle to old age, (ii) to assess the biological determinants predictive of maintenance of brain health, and (iii) to evaluate the impact of a controlled multi-dimensional lifestyle intervention on improving and maintaining brain health. The BBHI cohort consists of >4500 healthy participants aged 40–65 years followed through online questionnaires (Phase I) assessing participants’ self-perceived health and lifestyle factors in seven different domains: overall health, physical exercise, cognitive activity, sleep, nutrition, social interactions, and life purpose. In Phase II a sub-group of 1,000 individuals is undergoing detailed in-person evaluations repeated at two-yearly intervals. These evaluations will provide deep phenotyping of brain function, including medical, neurological and psychiatric examinations, assessment of physical fitness, neuropsychological assessments, structural and functional brain magnetic resonance imaging, electroencephalography and perturbation-based non-invasive brain stimulation evaluations of brain activity, as well as collection of biological samples. Finally, in Phase III a further sub-group of 500 participants will undergo a similar in-person assessment before and after a multi-dimensional intervention to optimize lifestyle habits and evaluate its effects on cognitive and brain structure and function. The intervention group will receive remote supervision through an ICT-based solution, with the support of an expert in health and lifestyle coaching strategies aimed at promoting adherence. On the other hand, the control group will not have this coaching support, and will only receive education and recommendations about healthy habits. Results of this three-part initiative shall critically contribute to a better understanding of the determinants to promote and maintain brain health over the lifespan.

Three types of sinkhole have been mapped in a 50 km 2 stretch of the Ebro River valley downstream of Zaragoza: large collapse sinkholes, large shallow subsidence depressions and small cover-collapse sinkholes. The sinkholes relate to the karstification of evaporitic bedrock that wedges out abruptly downstream, giving way to a shale substratum. Twenty-three collapse sinkholes, up to 50 m in diameter by 6 m deep, and commonly hosting saline ponds, have been identified in the floodplain. They have been attributed to the upward stoping of dissolutional cavities formed within the evaporitic bedrock by rising groundwater flows. Twenty-four large shallow subsidence depressions were mapped in the floodplain. These may reach 850 m in length and were formed by structurally controlled interstratal karstification of soluble beds (halite or glauberite? and gypsum) by rising groundwater flow and the progressive settlement of the overlying bedrock and overburden sediments. A total of 447 small cover-collapse, or dropout, sinkholes have been recognized in a perched alluvial level along the southern margin of the valley. These sinkholes result from the upward propagation of voids through the alluvial mantle caused by the downward migration of detrital sediments into dissolutional voids. The majority of these sinkholes, commonly 1·5-2 m in diameter, are induced by human activities. Over the karstic bedrock, there is a significant increase in sinkhole density downstream. This is interpreted as being a result of the evaporitic bedrock wedging out and the convergence of the groundwater flow lines in the karstic aquifer. The collapse sinkholes in this area, locally with a probability of occurrence higher than 140 sinkholes/km 2 /year, cause substantial damage to the linear infrastructures, buildings and agriculture, and they might eventually cause the loss of human lives.

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