No abstract

No abstract

INTRODUCTION: Observational studies have consistently shown that exercise triggers and accelerate disease progression in patients with arrhythmogenic cardiomyopathy (AC), and sports participation is generally restricted. Therefore, individuals with AC may be susceptible to engage in low physical activity levels. This study aimed to objectively describe the patterns of physical activity (PA), sedentary time (SED), and sleep in patients with AC and to examine the reproducibility of accelerometer-derived measures over four consecutive weeks. METHODS: A total of 71 (49.6 [SD=17.5] years) patients with AC wore a wrist-worn Axivity AX3 accelerometer for 30 consecutive days, and the raw signal was processed using the R-package GGIR. The participants were classified as meeting the 2020 World Health Organization guidelines using previously proposed thresholds for wrist accelerometers. The reproducibility of each metric was determined based on Intraclass Correlation Coefficients (ICCs; 95% CI) that were calculated using linear-mixed models adjusted for age, BMI, and season. RESULTS: In total, 59.2% of participants did not meet the physical activity guidelines. AC patients spent 71.1% of awake time in SED and only 2.5% of awake time in moderate-to-vigorous physical activity (MVPA). No significant differences were found in physical activity related variables between sex and age groups. However, patients ≥50 years (n= 33) spent longer periods of sedentary time in comparison to those <50 years (mean difference 38.9 min/d, 95% CI 5.8 to 72.2, p = <0.05), and participants with obesity (BMI ≥30 kg/m2, n= 10) accumulated longer periods of SED (mean difference 66.6 min/d, 95% CI 5.2 to 128.1, p = <0.05), and less MVPA (mean difference 22.8 min/d, 95% CI 0.7 to 44.9, p = <0.05) than those without obesity. The ICCs ranged from 0.67 for MVPA (95% CI=0.61, 0.72) to 0.92 for light-intensity physical activity (95% CI=0.89, 0.93) using a 7-day assessment period, however, stability improved for assessment periods of 14 days. CONCLUSION: Nearly 60% of the patients with AC did not meet the WHO 2020 physical activity guidelines. Accelerometer-based classifications of activity are moderately stable over time, indicating that a 7-day assessment period and to a greater extent a 14-day period provides a reproducible measure of physical activity, sedentary time and sleep.

No abstract

No abstract