Our review is limited by the small number and heterogeneity of studies identified: (1) an autopsy study describing elevated levels of CB receptor activity in the prefrontal cortex and suicide in both depression and alcoholism and (2) studies supporting the involvement of both CB and CB receptors in the regulation of neuropathic pain and stress-induced analgesia. We conclude that cannabinoid receptors, particularly CB receptors, may become promising targets for the development of novel therapeutic tools for the treatment of SB.
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