Community-acquired pneumonia (CAP) is a frequent cause of intensive care unit (ICU) admission in adults and the sixth leading cause of death worldwide. Although co-infections have been previously reported, the co-existence of
Streptococcus pneumoniae
and
Legionella pneumophila
is exceedingly rare. Despite the fact that
Streptococcus pneumoniae
is the most common etiology in the majority of cases, atypical organisms such as
Legionella pneumophila
should be considered as etiologic agents among all CAP cases that require hospitalization. Unlike
Legionella
, extra-pulmonary findings are uncommon in patients with
Streptococcus pneumoniae
pneumonia. In this report, the authors describe an unusual case of septic shock resulting from a combined
Legionella pneumophila
and
Streptococcus pneumoniae
infection associated with rhabdomyolysis, acute kidney injury, acute hypoxemic respiratory failure, pancreatitis, and acute liver injury.
Over the past several months we have learned about how pre-existent comorbidities may influence the outcome of patients infected with the coronavirus disease 2019 (COVID-19), with diabetes mellitus and obesity being commonly reported in association with increased mortality among these patients. In this report, the authors explore the case of a patient with Fragile-X Syndrome (FXS) who developed pneumonia due to COVID-19. FXS is an inherited cause of intellectual disability with potential neurologic and physiologic sequelae. In this narrative, we aim to describe how FXS may potentially play a role in the clinical course of patients with COVID-19.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.